플라즈마 중합된 아크릴산 및 하이드록시아파타이트 필름이 코팅된 3 차원 폴리카프로락톤 스캐폴드의 특성 및 생체적합성 평가
Characteristics and Biocompatibility of Three-Dimensional (3D) Polycaprolactone (PCL) Scaffold Coated with Plasma-Polymerized Acrylic Acid (PPAAc) and Hydroxyapatite (HAp) Film
이상준, 서기원, 고영무,
소속 상세정보
이상준 ( Lee Sang-June ) - 조선대학교 치의학전문대학원 치과재료학교실
서기원 ( Seo Ki-Won ) - 조선대학교 치의학전문대학원 치과재료학교실
고영무 ( Ko Yeong-Mu ) - 조선대학교 치의학전문대학원 치과재료학교실
KMID : 0362220120390040339
Abstract
In this study, we have prepared hydroxyapatite (HAp) coated three-dimensional (3D) polycaprolactone (PCL) scaffolds by plasma polymerization and biomimetic method, and then evaluated the biological behavior of MC3T3-E1 on the 3D PCL scaffolds surface coated with plasma-polymerized acrylic acid (PPAAc) thin film and HAp film. PPAAc thin film formed on the 3D PCL scaffolds was examined by contact angle measurement and fourier transform infrared spectroscopy. The results of surface characterization showed that PPAAc thin film indicated the hydrophilic surface property and contained the carboxyl groups. Nano-size crystals of HAp were uniformly coated on the modified 3D PCL scaffolds surface through the ionic interaction between the calcium ions and the carboxyl groups of PPAAc thin film. In vitro cell tests revealed that the surface modification of 3D PCL scaffolds with HAp nanocrystal improved the growth of the osteoblastic MC3T3-E1 cells and didn’t affect the cell differentiation.
키워드
Hydroxyapatite; Plasma polymerization; Polycaprolactone; Three-dimensional scaffolds
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